Mechanistic Basis of Arsenic Induced Carcinogenesis: Differential miRNA Expression

Arsenic, a toxic metalloid, provokes many detrimental consequences to human health. It is prevalent in earth’s crust and poses major threat humans globally. Inorganic arsenic exposure occurs mainly via drinking water or food metabolized mammals form organic metabolites/ end products. Chronic causes lung, skin urinary bladder cancers increases the risks of liver, kidney prostate cancers. Arsenic-induced ROS generation, disturbances several signaling pathways, DNA repair inhibition, chromosomal aberrations, epigenetic changes including alterations methylation, histone modifications differential miRNA expression profiles are involved cancer progression, malignant transformation. However, details arsenic-induced carcinogenesis molecular mechanisms still remaining obscure. MicroRNAs post-transcriptional gene regulators themselves may act as oncogenes tumor suppressor genes. Differential implicated This review covers general mechanistic basis carcinogenesis, explores recent in-vitro, in-vivo cohort studies on shares associated data dysregulation their functional leading induced tumorigenesis, metastasis cancer, also discusses future directions.